He received his doctoral degree from Princeton University in Lesk and Chothia also studied the conformations of antigen-binding sites of immunoglobulins. The discovery and analysis of these mechanisms was the key to understanding conformation changes in serine protease inhibitors, also known as serpins, mutations of which are an important cause of several diseases, including emphysema and certain types of inherited mental illness. Lesk used a systematic analysis of protein-folding patterns to develop a mathematical representation that aids in the recognition and classification of these patterns. He also wrote the first computer program to generate schematic diagrams of proteins using molecular graphics, and he developed many algorithms now used by other researchers to analyze the structures of proteins.

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Aimed primarily at a biological audience, it is ideal for those without detailed prior knowledge of programming who are encountering bioinformatics for the first time.

Frequent examples, self-test questions, problems, and exercises are incorporated throughout the text to encourage self-directed learning. Emphasises the practical applications of the subject to a wide range of disciplines, such as molecular biology, medicine, forensic science and anthropology. Invaluable information retrieval techniques and data calculations are covered to enable the reader to carry out their own research on the Web.

The Online Resource Centre includes data sets and Web-based problems, alongside guidance for answering the problems and exercises in the book. Two new chapters have been written to increase the coverage of metabolic pathways and gene expression and regulation, in order to reflect the recent growth of interest in these areas.

Extended coverage of genomics reflects the increasing cross-over between the disciplines of bioinformatics and genomics. Increased emphasis is placed on the exciting potential of bioinformatics to enable future advances in our understanding of life on earth A vast amount of biological information about a wide range of species has become available in recent years as technological advances have significantly reduced the time it takes to sequence a genome or determine a novel protein structure.

This text describes how bioinformatics can be used as a powerful set of tools for retrieving and analysing this biological data, and how bioinformatics can be applied to a wide range of disciplines such as molecular biology, medicine, biotechnology, forensic science and anthropology.

This reflects the recent growth of interest in these areas in the field of bioinformatics. Written primarily for a biological audience without a detailed prior knowledge of programming, this book is the perfect introduction to the field of bioinformatics, providing friendly guidance and advice on how to use various methods and techniques.

Furthermore, frequent examples, self-test questions, problems, and exercises are incorporated throughout the text to encourage self-directed learning. There are lots of quite innovative features which support the pedagogical delivery of the material. It is well-structured and nicely laid out. There are numerous examples and problems attached to each chapter, including the novel Weblems.


Arthur M. Lesk



Introduction to Bioinformatics


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