No trivia or quizzes yet. Want to Read saving…. Because the toxins are highly specific and extremely potent, they are employed as cell biological tools to decipher signal pathways in which their eukaryotic targets are involved. The studies aim to elucidate the mode of actions of toxins, toxin up-take and processing as well as the functional consequences of the action on signaling pathways of eukaryotic target cells. Andrea Frericks is currently reading it Jan 21, This book is not yet featured pjarmakologie Listopia.
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Understanding uptake and action of bacterial protein toxins We study the molecular mechanisms of several bacterial protein toxins, which are often very efficient enzymes. They covalently modify Rho GTPases by different modifications which lead to permanent activation of Rho proteins or to inhibition of downstream signaling.
Therefore, we use bacterial toxins as tools to study Rho-dependent physiological and pathophysiological signaling pathways. Key Papers: 1. Chem, 14 , Augspach, A. Toxins, 5 11 , Lang, S. Specific role of RhoC in tumor invasion and metastasis. Oncotarget, 8 50 , Several bacterial protein toxins catalyze covalent modifications of Rho proteins, thereby leading to permanent activation or inhibition of Rho signaling. Bacterial toxins are taken up by receptor-mediated endocytosis.
In recent years, several cellular membrane proteins have been identified which bind with high affinity and specificity to the toxins and mediate their endocytosis into mammalian cells.
We are interested in the question, whether bacterial toxins may activate or block signaling pathways downstream of their receptors. Moreover, we intend to engineer toxins with changed and defined cellular specificity with the aim to use the efficient and specific enzymes as potential pharmacological agents, for example to block movement of cancer cells. Piteau, M. PLoS Pathog, 10 1 , e Schmidt, G.
Novel receptors for bacterial protein toxins. Current Opinion in Microbiology, 23, 55— Zahaf, N. Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells. Sci Rep. Reppin, F. Toxins, 10 1 , 3. Many bacterial protein toxins are taken up into mammalian cells by receptor-mediated endocytosis modified from Schmidt et al. The entomopathogenic bacterium Photorhabdus luminescens produces an autonomous protein injection machinery.
One of our aims is to engineer this machinery for injection of diverse proteins and molecules into mammalian cells. Lang, A. Science, , Aktories, K. Curr Top Microbiol, , TcA is the injection machinery and mediates cell binding. The structure of the protein complex was solved recently by crystallography and cryo-electronmicroscopy.
Lang, Schmidt et al.
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