No placebo-treated patients withdrew due to nausea or vomiting. Because these events are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Drug Interactions: International normalized ratio INR increased with concomitant warfarin use sometimes associated with bleeding [see Drug Interactions 7. Neurologic: dysgeusia; somnolence Renal and Urinary Disorders: altered renal function, including increased serum creatinine, renal impairment, worsened chronic renal failure or acute renal failure sometimes requiring hemodialysis , kidney transplant and kidney transplant dysfunction [see Warnings and Precautions 5. BYETTA should be used with caution in patients receiving oral medications that have narrow therapeutic index or require rapid gastrointestinal absorption [see Adverse Reactions 6. For oral medications that are dependent on threshold concentrations for efficacy, such as contraceptives and antibiotics, patients should be advised to take those drugs at least 1 hour before BYETTA injection.
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Volabar Exenatide should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. Careful monitoring of blood glucose is recommended.
Let the autoinjector come to room temperature for approximately 15 minutes before administration. The ijsert is not indicated in infants or neonates. The concurrent use of exenatide with prandial insulin has not been studied. This product information is intended for US Healthcare Professionals only.
Thin or smaller individuals can use a 45 degree angle to avoid intramuscular injection. In Type 2 diabetes patients with partially intact insulin reserves, octreotide administration may result in decreases in plasma insulin levels and hyperglycemia. For patients who are to self-administering exenatide, adequate oral as well as written instructions on the use of the injector pen should be supplied before they self-administer a dose.
Hemodialysis Exenatide is not recommended for use in patients with end-stage renal disease ESRD on continuous or intermittent hemodialysis. The hyperglycemic effect of diazoxide is expected to be antagonized by certain antidiabetic agents e. Extended-release exenatide must be injected immediately after suspended in the diluent within the Pen device or the syringe. Do not store the pen with the needle on, as the medication may leak out or air bubbles may form in the cartridge.
Constituents in garlic might have some antidiabetic activity, and may increase serum insulin levels and increase glycogen storage in the liver. PDR Search Moderate Green tea catechins have been shown to decrease serum glucose concentrations in vitro. The two peaks represent the hydration and erosion of the microspheres. Among patients with end-stage renal disease receiving dialysis, the mean exenatide exposure increased by 3. Acetaminophen AUC, Cmax, and Tmax were not significantly changed when acetaminophen was given 1 h before exenatide injection.
Alternatively, administer before the 2 main meals of the day, approximately 6 hours or more apart. Exenatide has not been studied in patients with severe gastrointestinal GI disease, including gastroparesis. In some patients, hypoglycemia can be prolonged. This is followed by a gradual release of exenatide from the microspheres and a second peak around week 6 to 7. Moderate Cases of an increased INR have been reported with the concomitant use of warfarin and exenatide, sometimes associated with bleeding.
Exenatide AUC increased proportionally over the inset dose range of 5 to 10 mcg. Moderate Niacin nicotinic acid interferes with glucose metabolism and can result in hyperglycemia. Go to Healthcare Professional Site. Although specific dose recommendations are not available for most agents, the clinician should consider a dose packsge of the insulin secretagogue or insulin when used in combination with exenatide.
Exenatide also slows gastric emptying thereby reducing the rate at which meal-derived glucose appears in the circulation. Clonidine does not appear to impair recovery from hypoglycemia, and has not been found to impair glucose tolerance in diabetic patients.
Other oral hypoglycemics may also be considered as possible alternatives in some patients. Byetta exenatide dose, indications, adverse effects, interactions from Use is not recommended. Patients taking antidiabetic agents and receiving bortezomib treatment may require close monitoring of their blood glucose levels and dosage adjustment of their medication.
Volabar Exenatide should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. Careful monitoring of blood glucose is recommended. Let the autoinjector come to room temperature for approximately 15 minutes before administration. The ijsert is not indicated in infants or neonates.
BYETTA PACKAGE INSERT PDF
Patients should be advised to eat within 20 minutes of mecasermin administration. You are encouraged to report negative side effects of prescription drugs to the FDA. Even if the disposable needle is changed, sharing may result in transmission of hepatitis viruses, HIV, or other blood-borne pathogens. Patients at risk include those with compromised renal function, those fasting for prolonged periods, those that are malnourished, and those receiving high or excessive doses of sulfonamides.